The University of Texas at Arlington has successfully patented (Europe) an implantable medical device that attracts and kills circulating cancer cells


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The University of Texas at Arlington has successfully patented in Europe an implantable medical device that attracts and kills circulating cancer cells that was invented by a faculty member. This cancer trap can be used for early diagnosis and treatment of metastasized cancer.

“Our cancer trap works just like a roach motel, where you put in some bait and the roach goes there and dies,” said Liping Tang, UTA bioengineering professor and leader of the research. “We are putting biological agents in a cancer trap to attract and kill cancer cells.

“This method is effective for both diagnosing and treating metastasis cancer and can be used in combination with traditional chemotherapy and radiation therapy,” he added.

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Currently, there are many treatments for primary tumors but they do little to prevent metastasis and stray cancer cells from relocating to another part of the body. Surgical removal of cancerous tissue also can spur the spread of cancer in the body. While there are drugs given to patients after surgery to prevent cancer cells from adhering to each other or other tissues, these drugs do not rid the body of cancer cells or collect them to allow an assessment of the patient’s status.

“We have made a nano-sized device that we can put under the skin using an injection needle to recruit the cancer cells into a small area where we can treat them with less overall side effects to the whole body,” Tang said.

“So the cancer trap is really complementary to current cancer treatments and especially beneficial at the early stages when it is difficult to see if the cancer is spreading as there are few cancer cells. We have also found it very effective in late stage cancers to stop the spread of the disease and to prolong lifespan,” he added.

The cancer trap works by releasing different chemokines or regulatory proteins to attract circulating cancer cells and then expose them to chemotherapeutic agents to eradicate potential spreading. The trap has been tested in the lab and proved effective on many kinds of cancer cells, including melanoma, prostate cancer, breast cancer, lung cancer, leukemia and esophageal cancer.

“We are hoping to move toward clinical trials in the next few years as this technology could potentially significantly increase the lifespan of cancer patients,” Tang said.

This work on cancer forms part of a larger program at UTA where more than 30 faculty from different colleges and disciplines are developing new solutions to attack this disease.

With more than $4 million in research expenditures in 2017, UTA’s program for cancer encompasses basic cancer research, identification and diagnostics, as well as in noninvasive, midterm, invasive and postoperative therapies. UTA’s multidisciplinary research teams harness proficiencies from across science, engineering, computer science, nursing and kinesiology to tackle the challenges of precision oncology and cancer treatment.

Tang’s expertise encompasses a broad area, including stem cells, tissue engineering, nanotechnology, biocompatibility, biomaterials, inflammation, infection and fibrosis. He has published many of his work in high impact journals, including BiomaterialsJournal of Clinical InvestigationProceedings of the National Academy of SciencesBloodJournal of Experimental Medicine, and Tissue Engineering.

“Tang is a remarkable innovator and internationally recognized researcher,” said Michael Cho, UTA’s chair of bioengineering. “His work is a clear example of UTA’s strategic focus on health and the human condition and of the strength of multidisciplinary work.”

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NASA Chooses Microfluidic Electrochemical Reactor for Potential “Mission to Mars” Technology


nasa-symbolNASA has selected UT Arlington as one of four U.S. institutions to develop improved methods for oxygen recovery and reuse aboard human spacecraft, a technology the agency says is crucial to “enable our human journey to Mars and beyond.”
NASA’s Game Changing Development Program awarded $513,356 recently to the UT Arlington team. UT Arlington and three other teams are charged with the goal of increasing oxygen recovery to 75 percent or more.
Principal investigators on the UT Arlington project are Brian Dennis, associate professor of mechanical and aerospace engineering in the College of Engineering; Krishnan Rajeshwar, distinguished professor of chemistry and biochemistry in the College of Science; and Norma Tacconi, a research associate professor of chemistry and biochemistry.
from left: Krishnan Rajeshwar, Brian Dennis, and Norma Tacconi
Principal investigators on the UT Arlington project are from left: Krishnan Rajeshwar, distinguished professor of chemistry and biochemistry in the College of Science; Brian Dennis, associate professor of mechanical and aerospace engineering in the College of Engineering; and Norma Tacconi, a research associate professor of chemistry and biochemistry.
They will design, build and demonstrate a “microfluidic electrochemical reactor” to recover oxygen from carbon dioxide that is extracted from cabin air. The prototype will be built over the next year at the Center for Renewable Energy Science and Technology, CREST, at UT Arlington.
“At the end of this 15 month Phase I project, we will demonstrate the prototype to NASA officials. If we are selected to move to Phase II, we plan to build a full-scale unit. We hope the technology will be flight tested on the International Space Station sometime in the future,” Dennis said. “That’s what we’re really excited about and what we’ll be aiming for.”
Dennis said the design uses water and carbon dioxide as reactants and produces oxygen and hydrocarbon gases, such as methane. The gases can be vented into space and the oxygen is used for breathing.
“We have developed a nanocomposite electrode that speeds oxygen evolution at lower potential. That basically means it can produce more oxygen in a shorter time with less power and less reactor volume,” said Dennis. “This is important since power on a spacecraft is limited because it comes from solar panels and spacecraft capacity also is limited. Things should be as compact and lightweight as possible.”
Current methods of oxygen recovery used on the International Space Station, or ISS, achieve only about a 50 percent recovery rate. A better recovery rate means less oxygen needs to be stored and would free up precious cargo space on prolonged missions. With current technology, a trip to Mars would take about eight months, though scientists are working to shorten that time.
In a statement from NASA, Associate Administrator for Space Technology Michael Gazarak said improving oxygen recovery and designing a system with high reliability is crucial to long-duration human spaceflight.
“These ambitious projects will enable the critical life support systems needed for us to venture further into space and explore the high frontier and are another example of how technology drives exploration,” Gazarak said. NASA’s full announcement is available here.
Dennis said the proposed UT Arlington device has an advantage over the ISS method because not as much water is needed to achieve 75 percent recovery. The team estimates its system would require less water than what can be recovered in one day from a person’s sweat and urine. A water recovery system that converts bodily fluids to water is already at work on the ISS.
For years, Dennis, Rajeshwar and Tacconi have developed novel nanocomposites to be used in targeted electrochemical reactions for fuel cells and other purposes. The new project builds on that work and is another demonstration of the key role electrochemistry can play in technological advances, Tacconi and Rajeshwar said.
James Grover, interim dean of the UT Arlington College of Science, said the new NASA-funded project is a great chance for the College of Science and College of Engineering to make an impact in a field that captures human imagination and inspires innovation.
“Discoveries are cultivated through interdisciplinary collaboration and UT Arlington scientists and engineers have embraced that spirit to achieve advances,” Grover said.
Khosrow Behbehani, dean of the College of Engineering, said the interdisciplinary project speaks to practical aspects of space research.
“This project has great implication for space explorations,” Behbehani said. “Through collaboration of scientists and engineers at UT Arlington such innovations have become possible which can put us closer to exploring farther destinations in space.”
Source: University of Texas at Arlington

Read more: Microfluidic electrochemical reactor chosen by NASA as potential Mars mission technology